A facile synthesis of the GalNAcbeta1-->4Gal target sequence of respiratory pathogens |
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| Authors: | Autar Reshma Liskamp Rob M J Pieters Roland J |
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| Institution: | Utrecht Institute for Pharmaceutical Sciences, Department of Medicinal Chemistry, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands |
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| Abstract: | The carbohydrate sequence, GalNAcβ1→4Gal, is the target for the adhesion of several respiratory pathogens. The sequence was prepared in an optimized synthesis in forms that allow conjugation to scaffolds or surfaces. |
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| Keywords: | Bacterial adhesion GalNAcβ1&rarr 4Gal synthesis |
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