Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40) |
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| Authors: | Amitabha Basu Lorraine H Kligman Stefan J Samulewicz Chin C Howe |
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| Institution: | (1) The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA;(2) Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA;(3) Germantown High School, The School District of Philadelphia, Germantown Avenue and High Street, Philadelphia, PA 19104, USA |
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| Abstract: | Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examined the function of SPARC in cutaneous wound healing using SPARC-null mice and dermal fibroblasts derived from them. |
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