血管紧张素-(1-7)在动脉粥样硬化中的作用

血管紧张素-(1-7)［angiotensin(1-7), Ang-(1-7) ］是肾素-血管紧张素系 统(renin-angiotensin system, RAS)的新成员之一. 与血管紧张素Ⅱ(Ang Ⅱ)比 较，Ang-(1-7)在高血压及动脉粥样硬化等疾病中发挥着心血管保护作用. 最新研究 发现,Ang-(1-7)在平滑肌细胞增殖及迁移、内皮细胞功能、脂质代谢的这些动脉粥样硬化相关病理发展过程中起着重要作用，能够抑制动脉粥样硬化斑块的形成及加强斑块的稳定性. 本文就Ang-(1-7)与动脉粥样硬化疾病相关的最新研究进展进行综述，讨论Ang-(1-7)在动脉粥样硬化中的作用机制，也为Ang-(1-7)相关的ACE2/Ang -(1-7)/Mas轴作为未来临床治疗途径提供思路.

Effects of Angiotensin-(1-7) in the Pathogenesis of Atherosclerosis

Angiotensin-(1-7)［Ang-(1-7)］ is recognized as a bioactive peptidyl factor of the renin-angiotensin system (RAS). Different from Ang Ⅱ, Ang-(1-7) exerted cardiovascular protective effects in many diseases, including hypertension and atherosclerosis. Recent studies showed that Ang-(1-7) played an important role in the pathogenesis of atherosclerosis. Ang-(1-7) is able to reduce smooth muscle cell proliferation and migration, improve endothelial function, and decrease fat metabolism, thus to reduce atherosclerotic lesions and increase of plaque stability. In this review, we summarized the recent findings concerning the bioactivities of Ang-(1-7) in atherosclerosis and the related mechanism of Ang-(1-7) during atherosclerosis development. The potential therapeutic strategies targeting the ACE2/Ang-(1-7)/Mas axis were also discussed.