Immune responses to the pertussis toxin in Balb/c and C57B1/6 mice |
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| Authors: | J.M. Alonso F. Megret C. Brezin R.L. Friedman J.E. Alouf |
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| Affiliation: | Bacterial Ecology Unit, Department of Bacteriology and Mycology, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris Cedex 15, France;Bacterial Antigen Unit, Department of Bacteriology and Mycology, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris Cedex 15, France;Department of Microbiology and Immunology, University of Arizona, Tucson, AZ 86724, U.S.A. |
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| Abstract: | Abstract Immunization of Balb/c and C57B1/6 mice with the pertussis toxin (Ptx), purified from the culture supernatant of Bordetella pertussis (the whooping cough bacillus) resulted in different immune reactions in these genetically different strains of mice. Antibody responses to Ptx were detected only in Balb/c, whereas both Balb/c and C57B1/6 produced anti-Ptx antibodies when immunized with detoxified Ptx. Also, delayed-type hypersensitivity reactions differ strongly according to the use of Ptx or detoxified Ptx as eliciting antigen. |
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| Keywords: | Bordetella pertussis immune response pertussis toxin |
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