| Abstract: | Structural properties of blood plasma lipoproteins (LP) from coronary heart disease (CHD) patients were examined. Substantial differences were found in the pattern of the heat-induced structural restitution of LP of all classes in health and disease. At the same time no such differences were discovered in lipids isolated from LP. In high density lipoproteins from the plasma of CHD patients, a decrease in the microenvironmental polarity was shown to take place at a depth of 8 A from the surface of LP. The data obtained indicate substantial changes in the structural organization of LP of all classes in CHD. It is assumed that these changes are consequent on the modification of apoproteins and/or protein-lipid interactions in LP. |
