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Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters |
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| Authors: | Sandham David A Barker Lucy Beattie David Beer David Bidlake Louise Bentley David Butler Keith D Craig Sarah Farr David Ffoulkes-Jones Claire Fozard John R Haberthuer Sandra Howes Colin Hynx Deborah Jeffers Sarah Keller Thomas H Kirkham Paul A Maas Janet C Mazzoni Lazzaro Nicholls Andrew Pilgrim Gaynor E Schaebulin Elisabeth Spooner Gillian M Stringer Rowan Tranter Pamela Turner Katharine L Tweed Morris F Walker Christoph Watson Simon J Cuenoud Bernard M |
| Institution: | Novartis Institutes for Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom. david.sandham@pharma.novartis.com |
| Abstract: | A series of novel corticosteroid derivatives featuring C-17 furoate ester functionality have been synthesised. Profiling in vitro and in vivo has resulted in the identification of a compound with a longer duration of action and a lower oral side effect profile in rodents compared to budesonide. |
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