Interaction of human erythrocyte ghosts or liposomes with polyethylene glycol detected by fluorescence polarization |
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| Authors: | Hiroyuki Ohno Tohru Sakai Eishun Tsuchida Kenji Honda Shigeru Sasakawa |
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| Affiliation: | 1. Department of Polymer Chemistry, Waseda University, Shinjuku-ku, Tokyo 160, Japan;2. Central Blood Center, Japanese Red Cross Shibuya-ku, Tokyo 150, Japan |
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| Abstract: | The membrane fluidity of human erythrocyte ghost was temporarily increased by the addition of polyethylene glycol with molecular weight of 7500. On the other hand, the fluidity of dipalmitoylphosphatidyl choline bilayer liposomes was monotonously decreased by the addition of polyethylene glycol. Fusion of liposomes was inhibited by the interaction with polyethylene glycol. The temporary increase in membrane fluidity of erythrocyte ghosts was considered to be the result of the clustering of membrane-bound proteins which is believed to be one of the most important sequences in cell fusion. |
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| Keywords: | To whom correspondence should be addressed. |
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