The prealbumin nature of the amyloid protein in familial amyloid polyneuropathy (FAP)-Swedish variety |
| |
Authors: | Martha Skinner Alan S Cohen |
| |
Institution: | 1. Thorndike Memorial Laboratory, Boston City Hospital, Boston, Mass. USA;2. Division of Medicine, Boston City Hospital, Boston, Mass. USA;3. the Arthritis and Connective Tissue Disease Section, Evans Department of Clinical Research, Boston University School of Medicine, Boston, Mass. USA |
| |
Abstract: | Familial amyloid polyneuropathy (FAP) is a dominant hereditary type of amyloidosis affecting kinships originating in many countries. We have isolated a 15,000 dalton protein from the amyloid laden tissue of a patient of Swedish origin with familial amyloid polyneuropathy. By N-terminal sequence analysis it is homologous to the normal plasma protein, prealbumin. An antiserum prepared to the isolated protein confirms this by reacting identically with the amyloid protein and prealbumin. The normal plasma protein, prealbumin, is linked to a disease syndrome for the first time. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|