The effect of 4-isothiocyanatobenzene sulfonic acid on the oxygen affinity of human hemoglobin |
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| Authors: | Douglas L. Currell Bernice Law Michael Stevens Paul Murata Carmela Ioppolo Filippo Martini |
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| Affiliation: | Department of Chemistry California State University, Los Angeles, California 90032 USA;Consiglio Nazionale delle Richerche, Center of Molecular Biology Institute of Chemistry, School of Medicine University of Rome, Italy 00185 |
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| Abstract: | Human hemoglobin reacts with 4-Isothiocyanatobenzene sulfonic acid at the four amino groups of the N-terminal valines. The modified protein shows a decreased oxygen affinity over a wide pH range, a reduced alkaline Bohr effect, decreased co-operativity, and a reduced effect of inositol hexasulfate on the oxygen affinity. |
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| Keywords: | 4-ICBS 4-isothiocyanatobenzene sulfonic acid |
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