The comparative in vitro pharmacology of leukotriene D4 and its isomers |
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| Authors: | SRichard Baker John R Boot William B Jamieson David J Osborne WJohn F Sweatman |
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| Institution: | Lilly Research Centre Ltd. Erl Wood Manor Windlesham, Surrey GU20 6PH, England |
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| Abstract: | The 5R,6S and 5S,6R isomers of leukotriene D4 (LTD4), 9cis LTD4, 9cis,11trans LTD4 and 11trans LTD4 were synthesized for comparative pharmacological studies on intestinal and respiratory smooth muscle preparations. The 5S,6R isomers are biologically active, modification of the double bond stereochemistry causing only a moderate reduction in activity. The 5R,6S isomers possess approximately 1% the biological activity of their respective 5S,6R forms. |
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