Correlation between superoxide dismutase,glutathione peroxidase and catalase in isolated rat hepatocytes during fetal development |
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| Authors: | I Mavelli F Autuori L Dini A Spinedi MR Ciriolo G Rotilio |
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| Institution: | 1. Institute of Applied Biochemistry, University of Rome, Rome, Italy.;2. C.N.R. Center for Molecular Biology, University of Rome, Rome, Italy.;3. Institute of Histology and Embriology, Faculty of Science, University of Palermo, Italy.;4. Institute of Histology and Embriology, Faculty of Science, University of Rome, Rome, Italy.;5. Institute of Biological Chemistry, University of Rome, Rome, Italy. |
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| Abstract: | Superoxide dismutase, glutathione peroxidase and catalase activities were determined in isolated fetal rat hepatocytes of various ages and compared with the values of neonatal and adult cells. The developmental pattern of superoxide dismutase and glutathione peroxidase were very similar with a low constant activity in the fetal cells and a postnatal burst. On the contrary catalase begins to increase already since the 18th day of the fetal life. The results suggest a functional correlation of superoxide dismutase and glutathione peroxidase in the antioxidative enzyme defense of liver cells. |
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