Analgesic effect of antagonists of substance P |
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| Authors: | Fred Lembeck Karl Folkers Josef Donnerer |
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| Affiliation: | 1. Institute for Experimental and Clinical Pharmacology, Pain Research Commission of the Austrian Academy of Science, University of Graz, A-8010 Graz, Austria;2. Institute for Biomedical Research, The University of Texas at Austin, Austin, Texas 78712, U.S.A. |
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| Abstract: | [D-Pro2,D-Phe7,D-Trp9]-SP and [D-Pro2,D-Trp7,9]-SP havebeen shown to be antagonists of substance P. The hindlimb scratching syndrome of mice, known to be caused by substance P was absent when these peptides were injected into substance P-treated mice. Substance P shortens “tail withdrawal time” from hot water; the two peptides greatly prolonged tail withdrawal time. Antidromic stimulation of the saphenous nerve (rat), known to release substance P and to induce vasodilatation plasma extravasation, was also greatly inhibited by [D-Pro2,D-Phe7,D-Trp9]-SP. These peptides presumably cause anti-nociceptor effects (analgesia) by inhibition of substance P at receptors and favor the concept that substance P is a sensory neurotransmitter of nociceptive messages. |
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| Keywords: | SDS sodium dodecylsulfate VII polypeptide VII V polypeptide V UV ultraviolet light bp base pair(s) |
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