1,25-Dihydroxyvitamin D3 increases serum levels of the vitamin K-dependent bone protein |
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Authors: | Paul A. Price Sharon A. Baukol |
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Affiliation: | Department of Biology, University of California, San Diego La Jolla, California 92093 USA |
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Abstract: | 1,25-dihydroxyvitamin D3 increases serum levels of bone Gla protein (BGP). The maximal increase occurs 12 h after injection and is given by 350 ng 1,25(OH)2D3 per 180 g body weight. In both 2 and 11 month-old male rats, the maximal increase is about 3 times the normal level, while in 2 month old female rats, the maximal increase is 2 times the normal level. These effects of 1,25(OH)2D3 in rats parallel the previously described effects of the vitamin on BGP secretion by rat osteosarcoma cells in culture.BGP is the first bone-specific protein whose synthesis in animals is dramatically increased by 1,25(OH)2D3. The possible functions of BGP in the biological actions of 1,25(OH)2D3 on bone are discussed. |
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Keywords: | To whom correspondence should be addressed. |
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