Effect of polyamines on prostaglandin synthesis in various cell-free systems |
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Authors: | Kazuei Igarashi Reiko Honma Hiroko Tokuno Mitsukazu Kitada Haruo Kitagawa Seiyu Hirose |
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Institution: | Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Chiba 260, Japan |
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Abstract: | Synthesis of PGF2α by bovine uterus and guinea pig lung microsomes and that of TXB2 by human platelet and rat spleen microsomes were stimulated by spermine. PGE2 synthesis by bovine seminal vesicle and porcine lung microsomes, and 6-keto-PGF1α synthesis by bovine seminal vesicle and uterus microsomes were inhibited by spermine. When phospholipid-free prostaglandin synthetase from bovine seminal vesicle was used instead of microsomes, the inhibition of PGE2 synthesis by spermine disappeared. The inhibition of PGE2 synthesis by spermine gradually appeared with an increase of phospholipid added. Among phospholipids tested, phosphatidylcholine was the most effective for the inhibition of PGE2 synthesis by spermine. |
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