A proposed mechanism of normal intestinal lactase decline in the postweaned mammal |
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Authors: | K.K. Tsuboi L.K. Kwong J. Neu P. Sunshine |
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Affiliation: | Department of Pediatrics Stanford University Medical Center Stanford, CA 94305 USA |
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Abstract: | Intestinal lactase declines to low levels in the postweaned mammal as an adaptation to normal termination of lactose ingestion. Although a well known phenomenon and presumably the basis of milk intolerance among most human adults, the mechanism of this decline has remained obscure. Evidence is presented to support a proposal that temporally related cytokinetic changes, which effect a generally corresponding reduction in enterocyte life-span, serve as the causal basis of lactase decline in the postweaned mammal. |
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