Effects of 1-methyl cyclohexane carboxylic acid (CCA) on cellular energetics in neuroblastoma cells |
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| Authors: | Bernard Croizat Francis Berthelot Marie-Madeleine Portier Hélène Ohayon François Gros |
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| Affiliation: | 1. Laboratoire de Biochimie Cellulaire, Collège de France, 75231 Paris Cedex 05, France;1. Service de Microscopie Electronique, Institut Pasteur, 75015 Paris, France |
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| Abstract: | The level of cellular energetics has been estimated in neuroblastoma cells under different culture conditions. The cellular accumulation of isomerase-2-deoxy [14C]D-glucose-6-phosphate was taken as reflecting glucose utilization. A considerably higher amount of radioactivity — 2.5 to 4 times — is found in CCA treated cells, as compared to other types of cultures, corresponding to a higher rate of deoxyglucose penetration and utilization. |
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| Keywords: | 2DG 2-deoxy D-glucose 2DG-6-P 2-deoxy D-glucose-6-phosphate dimethyl sulfoxide |
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