Analysis of phorbol ester receptors in phorbol ester unresponsive 3T3 cell variants |
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| Authors: | Peter M Blumberg Edith Butler-Gralla Harvey R Herschman |
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| Institution: | 1. Department of Pharmacology, Harvard Medical School; Boston, MA 02115 USA;2. Department of Biological Chemistry, Molecular Biology Institute; Los Angeles, CA 90024 USA;3. Laboratory of Biomedical and Environmental Sciences; UCLA Center for the Health Sciences; Los Angeles, CA 90024 USA |
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| Abstract: | The phorbol ester tumor promoters induce multiple cellular responses in cell culture, including mitogenesis. We have analyzed 3 variants of mouse 3T3 cells mitogenically unresponsive to the phorbol esters for phorbol ester receptors. All resembled control 3T3 cells in their specific 3H]phorbol 12,13-dibutyrate binding. The variants thus appear to be altered at steps distal to receptor occupancy in the mitogenic response to the phorbol esters. |
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