Lysosomal pool of free-amino acids |
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| Authors: | Erik Harms Nathan Gochman Jerry A. Schneider |
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| Affiliation: | 1. Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 USA.;2. Department of Pathology, University of California, San Diego, La Jolla, CA 92093 USA.;3. Laboratory Services, Veterans Administration Hospital, San Diego, CA 92161 USA. |
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| Abstract: | Free (non-protein) amino acids were measured in whole rat liver and in unmodified lysosomes which were prepared from rat liver by the technique of free-flow electrophoresis. Significant intralysosomal pools of threonine, serine, valine, cystine, methionine, isoleucine, leucine, tyrosine, phenylalanine, lysine and arginine were found. No efflux occurred from rat liver lysosomes in isotonic buffered sucrose at 0°C, but all amino acids showed various degrees of efflux at 200 and 370. |
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