严重急性呼吸综合征(SARS)冠状病毒抗体的检测及其临床意义 |
| |
引用本文: | 陈心春,王火生,李美忠,杨桂林,徐六妹,王辉,李丽雄,周伯平.严重急性呼吸综合征(SARS)冠状病毒抗体的检测及其临床意义[J].病毒学报,2003,19(3):271-273. |
| |
作者姓名: | 陈心春 王火生 李美忠 杨桂林 徐六妹 王辉 李丽雄 周伯平 |
| |
作者单位: | 深圳市东湖医院,深圳,518020 |
| |
摘 要: | To investigate the k inetics of antibody to SARS coronavirus in SARS patients and its clinical implication,ELISA was used to dete ct antibody to SARS coronavirus(SA RS CoV),RT-PCR was used to detect the SARS CoV RNA and,besides,the C D+4 and CD+8 T cells in peripheral blood of SARS patients and healthy controls were assayed by flowcytom etryThe results showed that SARS CoV IgM were first detected from da y 7 to day 47 after SARS onset,wit h average at day 193±101SARS Co V IgG were first detected from day 4 to day 47 after SARS onset,with average at day 207±101,and the p roduction of SARS CoV IgG was corr elated with CD+4 T cell number(P<005),but had no relationship with SARS CoV RNAMost SARS patients pr oduced SARS CoV antibody,IgM produ ced almost at the same time wit h IgGSARS CoV IgG is a protective antibody against SARS CoV and the titer of IgG may be used as an ind ex indicating the specific immunit y production in SARS patients
|
关 键 词: | 严重急性呼吸综合征 SARS 冠状病毒 抗体 酶联免疫吸附试验 |
文章编号: | 1000-8721(2003)03-0271-03 |
Detection of Antibody to SARS Coronavirus in SARS Patients and Its Clinical Implication |
| |
Abstract: | |
| |
Keywords: | severe acute respirat ory syndrome(SARS) antibody SARS coro navirus enzyme-linked immunosorben t assay(ELISA) |
本文献已被 CNKI 维普 万方数据 等数据库收录! |
|