Impairment of primary in vitro response of New Zealand mouse spleen cells to a thymic-dependent antigen. |
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Authors: | S S Kassan T M Chused |
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Institution: | Clinical Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014 USA |
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Abstract: | New Zealand Black (NZB) and NZB by New Zealand White (NZW) F1 hybrid () mice develop clinical signs of autoimmune disease between 6 and 10 months of age but spleen cells from these strains have a greatly reduced in vitro response to sheep erythrocytes (SRBC) as early as 5–6 weeks of age. This hyporesponsiveness can be only partially restored with 2-mercaptoethanol, allogeneic macrophages or spleen cells, or allogeneic factor. The response of NZB and spleen cells to the thymic independent antigen DNP-Ficoll is nearly normal. The reduced in vitro SRBC response was found to be attributable to splenic T and B cells rather than macrophages. Macrophages from NZB mice were found to function normally. The in vitro behavior of NZB lymphocytes is very similar to non-autoimmune mice infected with common murine viral pathogens. NZB and mice may be making an active immune response as early as 5 weeks of age. |
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