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The structure, catalytic mechanism and regulation of adenylyl cyclase |
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| Authors: | John JG Tesmer Stephen R Sprang |
| Affiliation: | Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9050, USA |
| Abstract: | The recent structure determinations of the mammalian effector enzyme adenylyl cyclase reveal the structure of its catalytic core, provide new insights into its catalytic mechanism and suggest how diverse signaling molecules regulate its activity. |
| Keywords: | Abbreviations: 2'd3'AMP 2'-deoxy-3'-AMP IIC2 AC2 C2a domain AC adenylyl cyclase C cytoplasmic domain CaM calmodulin Gβγ G protein βγ subunits Giα inhibitory G protein α subunit Gsα stimulatory G protein α subunit M membrane-spanning domain myr myristoylated N N-terminal domain PK protein kinase PPi pyrophosphate VC1 AC5 C1a domain |
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