Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix |
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| Authors: | Hazel Tapp,Ray Deepe,Jane A Ingram,Marshall Kuremsky,Edward N Hanley Suffix" >Jr,Helen E Gruber |
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| Affiliation: | (1) Department of Orthopaedic Surgery, Carolinas Medical Center, 28232, 1000 Blythe Blvd, Charlotte, NC, USA |
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| Abstract: | Introduction Adult mesenchymal stem cell therapy has a potential application in the biological treatment of disc degeneration. Our objectives were: to direct adipose-derived mesenchymal stem cells (AD-MSC) from the sand rat to produce a proteoglycan and collagen type I extracellular matrix (ECM) rich in known ECM components of the annulus fibrosis of disc; and to stimulate proteoglycan production by co-culture of human annulus cells with AD-MSC. |
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