Correlation of low molecular weight advanced glycation end products and nitric oxide metabolites with chronic complications in type 1 diabetic patients |
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Authors: | Constantina Heltianu Simona-Adriana Manea Cristian Guja Carina Mihai Constantin Ionescu-Tirgoviste |
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Institution: | (1) Institute of Cellular Biology and Pathology “N. Simionescu”, 050568 Bucharest, Romania;(2) Institute of Diabetes, Nutrition and Metabolic Diseases “Prof. N.C. Paulescu”, 020475 Bucharest, Romania;(3) “Carol Davila” University of Medicine and Pharmacy, 050471 Bucharest, Romania |
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Abstract: | Advanced glycation end products (AGEs) are involved in the occurrence of vascular complications in diabetes. The present study
was undertaken to investigate the level of low-molecular weight products of AGEs (LMW-AGEs) in relation to microvascular complications
in type 1 diabetes, and the possible relationship with nitric oxide (NO) as a marker of endothelial function. Patients with
normal renal function (NRF) were classified into two groups: (1) without, and (2) with diabetic neuropathy; and patients with
renal impairment also into two groups: (3) diabetic renal disease, and (4) end-stage renal disease. The fluorescence of LMW-AGEs
and measurement of NO metabolites was assessed in 277 serum samples. In addition, multiple regression analysis was performed.
In group 1, LMW-AGEs level (9.3±1.1 AF%) was higher than in the control group (2.4±0.3 AF%). A trend in the increase of LMW-AGEs
with neuropathy (29.7±5.5 AF%, group 2), and further with renal impairment (47.0±8.0, group 3 and 137.8±25.5 AF%, group 4),
was observed. In multivariate regression analysis LMW-AGEs were associated with NO metabolites in group 2. In NRF patients,
diabetic neuropathy was significantly correlated with LMW-AGEs and NO metabolites, independently of serum creatinine and duration
of diabetes. This relationship suggests that the NO and LMW-AGEs’ actions (possibly synergistic) in endothelial activation
possess a role in the initiation and development of diabetic microvascular complications. |
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Keywords: | Low-molecular weight-AGEs Type 1 diabetes Nitric oxide Neuropathy Renal function |
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