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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
Authors:Ron D. Jachimowicz  Filippo Beleggia  Jörg Isensee  Bhagya Bhavana Velpula  Jonas Goergens  Matias A. Bustos  Markus A. Doll  Anjana Shenoy  Cintia Checa-Rodriguez  Janica Lea Wiederstein  Keren Baranes-Bachar  Christoph Bartenhagen  Falk Hertwig  Nizan Teper  Tomohiko Nishi  Anna Schmitt  Felix Distelmaier  Hermann-Josef Lüdecke  Yosef Shiloh
Affiliation:1. The David and Inez Myers Laboratory for Cancer Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel;2. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel;3. Clinic I of Internal Medicine, University Hospital Cologne, Cologne 50931, Germany;4. Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany;5. Institute of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany;6. Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital Cologne, Cologne 50931, Germany;7. Department of Translational Molecular Medicine, Division of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, USA;8. Institute for Genome Stability in Aging, Cologne, Germany;9. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide and Department of Genetics, University of Sevilla, Sevilla 41092, Spain;10. Department of Experimental Pediatric Oncology, University Hospital Cologne, Cologne, Germany;11. Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany;12. Department of Pediatric Oncology and Hematology, Charité, Berlin, Germany;13. German Cancer Consortium, Germany;14. Berlin Institute of Health, Germany;15. Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Heinrich-Heine-University, Düsseldorf 40225, Germany;16. Institute of Human Genetics, University Clinic Duisburg-Essen, Essen, Germany;17. Department of Translational Genomics, University of Cologne, Cologne, Germany
Abstract:
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  • Keywords:DNA damage  DNA double-strand break repair  homologous recombination  non-homologous end joining  cancer  targeted cancer therapy  UBQLN4 deficiency syndrome  genome instability syndrome  ubiquitin  proteasomal degradation
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