| 代谢调节剂对紫杉醇和Taxuyunnanine C生物合成的调控作用 |
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| 引用本文： | 周忠强,梅兴国. 代谢调节剂对紫杉醇和Taxuyunnanine C生物合成的调控作用[J]. 天然产物研究与开发, 2005, 17(4): 401-403 |
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| 作者姓名： | 周忠强 梅兴国 |
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| 作者单位： | 1. 中南民族大学化学与材料科学学院,武汉,430074
2. 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家863基金项目(102120601) |
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| 摘 要： | 研究了诱导子、前体和抑制剂对东北红豆杉生产紫杉醇和taxuyunnanine C的影响。结果表明，诱导子在第12d添加，前体和抑制剂在第15d添加能有效地提高紫杉醇和taxuyunnanine C的含量。水杨酸与氯化氯胆碱的交互作用对紫杉醇的合成有很大影响，水杨酸与赤霉酸的交互作用对taxuyunnanine C的合成有很大影响。
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| 关 键 词： | 紫杉醇 taxuyunnanine C 诱导子 前体 抑制剂 细胞悬浮培养 |
| 修稿时间： | 2005-01-10 |
Taxol and Taxuyunanine C Biosynthesis Regulated by Metabolite Regulators |
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| ZHOU Zhong-qiang,MEI Xing-guo. Taxol and Taxuyunanine C Biosynthesis Regulated by Metabolite Regulators[J]. Natural Product Research and Development, 2005, 17(4): 401-403 |
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| Authors: | ZHOU Zhong-qiang MEI Xing-guo |
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| Affiliation: | ZHOU Zhong-qiang~1*,MEI Xing-guo~2 |
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| Abstract: | The effects of some elicitor, precursors and inhibitors on production of taxol and taxuyunnanine C in cell suspension cultures of T. cuspisata were studied. The results showed that the addition of elicitor on the 12th day,the addition of precurors and inhibors on the 15th day to the cultures may dramatically increase the production of taxol and taxuyunnanine C. The interaction of salicylic acid with chlorocholine chloride is significant for biosynthesis of taxol,and the interaction of salicylic acid with gibberellin is significant for biosynthesis of taxuyunnanine C. |
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| Keywords: | taxol taxuyunnanine C elicitor precursor inhibitor cell suspension culture |
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