| 表观遗传调控在糖尿病及其并发症中的作用 |
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| 引用本文： | 凌宏艳,胡弼,奉水东,廖端芳,文格波. 表观遗传调控在糖尿病及其并发症中的作用[J]. 生物化学与生物物理进展, 2012, 39(1): 14-21 |
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| 作者姓名： | 凌宏艳 胡弼 奉水东 廖端芳 文格波 |
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| 作者单位： | 南华大学;南华大学;南华大学;湖南中医药科大学;南华大学 |
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| 基金项目： | 国家自然科学基金 (81000328, 30971170)和南华大学博士科研启动基金(2010XQD39)资助项目 |
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| 摘 要： | 表观遗传(epigenetics)是指DNA序列不发生变化但基因表达却发生了可遗传的改变．表观遗传调控过程十分复杂，主要包括DNA甲基化、组蛋白修饰和微小RNA(miRNA)等．糖尿病是一种慢性代谢性疾病，常伴随大血管和微血管并发症．糖尿病的发生、发展不仅取决于遗传因素，而且也受到表观遗传修饰的调控．因此，对表观遗传调控的研究将为糖尿病及其并发症的预防和治疗提供新的思路和方法．
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| 关 键 词： | 表观遗传调控，糖尿病，糖尿病并发症 |
| 收稿时间： | 2011-05-26 |
| 修稿时间： | 2011-07-20 |
The Role of Epigenetic Regulation in Diabetes and Its Complications |
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| LING Hong-Yan,HU Bi,FENG Shui-Dong,LIAO Duan-Fang and WEN Ge-Bo. The Role of Epigenetic Regulation in Diabetes and Its Complications[J]. Progress In Biochemistry and Biophysics, 2012, 39(1): 14-21 |
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| Authors: | LING Hong-Yan HU Bi FENG Shui-Dong LIAO Duan-Fang WEN Ge-Bo |
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| Affiliation: | 1) Department of Physiology,School of Medicine,University of South China,Hengyang 421001,China; 2) Center for Basic Medical Post-doctoral Studies,University of South China,Hengyang 421001,China; 3) Department of Epidemiology,School of Public Health,University of South China,Hengyang 421001,China; 4) School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China; 5) Institute of Clinical Research,The First Affiliated Hospital,University of South China,Hengyang 421001,China) |
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| Abstract: | Epigenetics indicates the heritable changes in gene expression without nucleotide sequence variation. The process of epigenetic regulation is very complex, which mainly includes DNA methylations, histone modifications and miRNA. Diabetes is a chronic metabolic disease accompanied with macrovascular and microvascular complications. The development of diabetes not only depends on genetic factors, but also is regulated by epigenetic regulation. Therefore, further exploration into epigenetic regulation will provide new ideas and methods to the prevention and treatment for diabetes and its complications. |
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| Keywords: | epigenetic regulation diabetes diabetic complications |
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