Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma |
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Authors: | Cristiana Pistol Tanase Simona Dima Mihaela Mihai Elena Raducan Mihnea Ioan Nicolescu Lucian Albulescu Bogdan Voiculescu Traian Dumitrascu Linda Maria Cruceru Mircea Leabu Irinel Popescu Mihail Eugen Hinescu |
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Institution: | (1) “Victor Babes” National Institute of Pathology, 99-101 Splaiul Independentei, Bucharest, 050096, Romania;(2) Fundeni Clinical Institute, 258 Soseaua Fundeni, Bucharest, Romania;(3) Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroilor Sanitari Blvd, Bucharest, Romania |
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Abstract: | The assessment of caveolin-1 (Cav-1) as a marker of tumor aggressiveness in pancreatic ductal adenocarcinoma (PDAC). In this
study, we examined the expression of Cav-1 in 34 human PDAC tissue samples and the associated peritumoral tissues by immunohistochemistry
and western blot. Additionally, we correlated Cav-1 expression with other tissue (Ki-67, p53) and serum (CA 19-9) tumor markers.
In the tumor-derived tissue, both tumor cells and blood vessels expressed Cav-1. In contrast, in peritumoral tissue, Cav-1
expression was confined mainly to blood vessels and was only occasionally expressed in ductal or parenchymal cells. Western
blot analysis confirmed the overexpression of Cav-1 in pancreatic tumors compared with peritumoral tissue. Cav-1 expression
in tumor tissues was correlated with both the Ki-67 LI (r = 0.95, P < 0.0001) and p53 expression (χ2 = 9.91, P < 0.005). Overexpression of Cav-1 was associated with tumor size, grade and stage and Cav-1 expression in tumors was correlated
with an increased serum level of CA 19-9 (r = 0.795, P < 0.001). Based on the results of this study, the inclusion of Cav-1 in a putative panel of biomarkers predicting pancreatic
cancer aggressiveness is warranted. |
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Keywords: | Caveolin-1 Pancreatic ductal carcinoma Immunohistochemistry Western blot Ki-67 and p53 |
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