Use and comparison of different internal ribosomal entry sites (IRES) in tricistronic retroviral vectors期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Use and comparison of different internal ribosomal entry sites (IRES) in tricistronic retroviral vectors

Authors:	Victorine?Douin,Stephanie?Bornes,Laurent?Creancier,Philippe?Rochaix,Gilles?Favre,Anne-Catherine?Prats,Bettina?Couderc author-information" > author-information__contact u-icon-before" > mailto:couderc_b@icr.fnclcc.fr" title=" couderc_b@icr.fnclcc.fr" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	1.Department of ? Innovations thérapeutiques en Oncologie ?, INSERM U563,Institut Claudius Regaud,Toulouse,France;2.Inserm U569, Institut Fédératif de Recherche Louis Bugnard,CHU Rangueil, Chemin du Vallon,Toulouse,France

Abstract:	Background Polycistronic retroviral vectors that contain several therapeutic genes linked via internal ribosome entry sites (IRES), provide new and effective tools for the co-expression of exogenous cDNAs in clinical gene therapy protocols. For example, tricistronic retroviral vectors could be used to genetically modify antigen presenting cells, enabling them to express different co-stimulatory molecules known to enhance tumor cell immunogenicity.

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