Polyadenylation of ribosomal RNA by Candida albicans also involves the small subunit |
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| Authors: | Jacob Fleischmann Hong Liu Chieh-Pin Wu |
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| Institution: | (1) Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA;(2) Department of Oral Biology and Medicine, UCLA School of Dentistry, University of California, 10833 Le Conte Ave., Los Angeles, California 90095, USA |
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| Abstract: | Background
Candida albicans is a polymorphic fungus causing serious infections in immunocompromised patients. It is capable of shifting from yeast to
germinating forms such as hypha and pseudohypha in response to a variety of signals, including mammalian serum. We have previously
shown that some of the large 25S components of ribosomal RNA in Candida albicans get polyadenylated, and this process is transiently intensified shortly after serum exposure just prior to the appearance
of germination changes. |
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