Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: The Human GPCR-DB Database |
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Authors: | Claes Wahlestedt Anthony J Brookes Salim Mottagui-Tabar |
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Affiliation: | (1) Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius v?g 35, 17177 Stockholm, Sweden;(2) Department of Genetics, University of Leicester, University Road, LE1 7RH, Leicester, UK |
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Abstract: | Background We have surveyed, compiled and annotated nucleotide variations in 338 human 7-transmembrane receptors (G-protein coupled receptors). In a sample of 32 chromosomes from a Nordic population, we attempted to determine the allele frequencies of 80 non-synonymous SNPs, and found 20 novel polymorphic markers. GPCR receptors of physiological and clinical importance were prioritized for statistical analysis. Natural variation and rare mutation information were merged and presented online in the Human GPCR-DB database . |
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