CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig |
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| Authors: | Vacca Carmine Fallarino Francesca Perruccio Katia Orabona Ciriana Bianchi Roberta Gizzi Stefania Velardi Andrea Fioretti Maria Cristina Puccetti Paolo Grohmann Ursula |
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| Affiliation: | Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy. |
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| Abstract: | The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4. |
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