Occupational levels of radiation exposure induce surface expression of interleukin-2 receptors in stimulated human peripheral blood lymphocytes |
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Authors: | Yindong Xu C L Greenstock A Trivedi R E J Mitchel |
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Institution: | (1) Present address: Infectious Disease Clinic, University of British Columbia, 667-1081 Burrard Street, V6Z 1Y6 Vancouver, BC, Canada;(2) Radiation Biology and Health Physics Branch, AECL, K0J 1J0 Chalk River, Ontario, Canada |
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Abstract: | Interleukin-2 (IL-2) is a cytokine responsible for a variety of immune and non-immune stimulatory and regulatory functions,
including the activation and stimulation of cytotoxic cells able to recognize and kill human tumour cells and T-cell proliferation
and differentiation. We show that low doses of radiation, in the range commonly received by atomic radiation workers or as
a result of minor medical diagnostic procedures (0.25 to 10 mGy), stimulate the expression of IL-2 receptors (IL-2R) on the
surface of peripheral blood lymphocytes (PBL) taken from normal human donors. This stimulated surface expression after in
vitro irradiation is an indirect effect, resulting from the secretion into the medium of a soluble factor from the irradiated
cells. This factor can also stimulate IL-2R surface expression in unirradiated cells. Consequently, radiation stimulation
of IL-2R expression in a large population of PBL shows a triggered-type response rather than being proportional to dose. These
results demonstrate that normal human cells can respond to doses of radiation in the range of common occupational or medical
exposures. The data also demonstrate a possible defence mechanism against environmental stress by which a radiation-exposed
cell can use an indirect signalling mechanism to communicate with and influence the biological processes in an unexposed cell. |
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