|
|||||
|
|
Malignant glioma progression and nitric oxide |
|
| Authors: | Lam-Himlin Dora Espey Michael G Perry George Smith Mark A Castellani Rudy J |
| Institution: | aDepartment of Pathology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA bRadiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA cDepartment of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA dCollege of Sciences, University of Texas at San Antonio, San Antonio, TX, USA |
| Abstract: | Glioblastoma multiforme, the most common of the malignant gliomas, carries a dismal prognosis in spite of the most aggressive therapy and recent advances in molecular pathways of glioma progression. Although it has received relatively little attention in the setting of malignant gliomas, nitric oxide metabolism may be intimately associated with the disease process. Interestingly, nitric oxide has both physiological roles (e.g., neurotransmitter-like activity, stimulation of cyclic GMP), and pathophysiological roles (e.g., neoplastic transformation, tumor neovascularization, induction of apoptosis, free radical damage). Moreover, whether nitric oxide is neuroprotective or neurotoxic in a given disease state, or whether it enhances or diminishes chemotherapeutic efficacy in malignant neoplasia, is unresolved. This review discusses the multifaceted activity of nitric oxide with particular reference to malignant gliomas. |
| Keywords: | Nitric oxide Nitric oxide synthase Glioma Glioblastoma multiforme |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |