| Production of TMC-151, TMC-154 and TMC-171, a new class of antibiotics, is specific to ‘Gliocladium roseum’ group |
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| 收稿时间： | 20 April 2009 |
| 修稿时间： | 17 April 2000 |
Production of TMC- 151, TMC- 154 and TMC- 171, a new class of antibiotics,is specific to ‘Gliocladium roseum’ group |
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| Authors: | Toru Okuda Jun Kohno Noboru Kishi Yasuyuki Asai Maki Nishio Saburo Komatsubara |
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| Institution: | (1) Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, 335-8505 Toda, Saitama, Japan;(2) Present address: Tamagawa University Research Institute, 6-1-1, Tamagawa-Gakuen, 194-8610 Machida, Tokyo, Japan |
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| Abstract: | A novel class of fungal metabolites, TMC-151, TMC-154, and TMC-171 series compounds, was found exclusively inGliocladium catenulatum, Clonostachys rosea and closely related strains. These compounds were not detected in any other fungi examined. The production spectrum of each
component was correlated to the morphology of the secondary conidiophores and the conidia. TMC-151 was limited toClonostachys rosea (formerlyG. roseum) forming navicular or reniform conidia orG. catenulatum with gray-green conidial masses, whereas TMC-154 and 171 were limited to the strains closely related toGliocladium roseum, which grew more slowly and formed more symmetrical conidia. |
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| Keywords: | Clonostachys compactiuscula Clonostachys rosea Gliocladium catenulatum Gliocladium roseum |
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