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Autoradiographic localization of substance P receptors using I substance P |
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| Authors: | C.W. Shults R. Quirion R.T. Jensen T.W. Moody T.L. O''Donohue T.N. Chase |
| Affiliation: | * Experimental Therapeutics Branch, NINCDS, USA † Digestive Diseases Branch, NIADDK, USA ‡ Dept. of Biochemistry, School of Medicine, George Washington University, Washington, D.C., USA § Section on Brain Biochemistry, Clinical Neuroscience Branch, NIMH, USA |
| Abstract: | This paper describes a method for localization of substance P receptors in the rat central nervous system using 125I labeled substance P in an autoradiographic procedure. Particularly high densities of substance P receptors were observed in the olfactory bulb, dentate gyrus, amygdala, superior colliculus, and locus coeruleus. Surprisingly low densities of substance P receptors were found in the substantia nigra pars reticulata, a region which contains high concentrations of substance P. |
| Keywords: | Receptors Neuropeptide Substance P Autoradiography |
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