GM3 ganglioside induces hamster fibroblast growth inhibition in chemically-defined medium: ganglioside may regulate growth factor receptor function |
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| Authors: | E G Bremer S Hakomori |
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| Institution: | 1. Biochemical Oncology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104 USA;2. University of Washington, Seattle, WA 98104 USA |
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| Abstract: | GM3 or GM1 ganglioside exogenously added in chemically-defined medium incorporate equally into cells. However, only GM3 showed a significant growth inhibition to hamster fibroblasts (BHK). The GM3-fed cells became refractory to growth stimulation by fibroblast growth factor (FGF) in chemically-defined media. Radiolabeled FGF accumulated on GM3-fed cells, but not on GM1-fed cells. Both GM3 and GM1 did not directly interact with FGF. These data suggest that GM3 may regulate the function of the receptors for growth hormones. |
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