A library construction of 2,5-disubstituted pyrrole compounds by using solid/solution-phase syntheses |
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| Authors: | Kobayashi Naoki Kaku Yumiko Higurashi Kunizo Yamauchi Toshihiko Ishibashi Akira Okamoto Yasushi |
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| Institution: | Discovery Technology Research Laboratories, Eisai Co., Ltd., 1-3, Tokodai 5-chome, Tsukuba-shi, Ibaraki 300-2635, Japan. n2-kobayashi@hhc.eisai.co.jp |
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| Abstract: | Using solid- and solution-phase synthesis, a library of 2,5-disubstituted pyrrole compounds was constructed. This is the first report that Stetter reaction was applied to the solid-phase synthesis for C-C bond formation. Some of 2,5-disubstituted pyrrole compounds showed the inhibitory activity of LPS-induced mouse B-lymphocyte proliferation. |
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