| 朊粒蛋白PrP~(Sc)寡聚体的形成与跨膜毒性 |
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| 引用本文： | 衡杰,吴琦.朊粒蛋白PrP~(Sc)寡聚体的形成与跨膜毒性[J].中国生物化学与分子生物学报,2010,26(2):109-115. |
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| 作者姓名： | 衡杰 吴琦 |
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| 作者单位： | 四川农业大学生命科学与理学院，四川雅安625000 |
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| 摘 要： | 朊粒蛋白(prionprotein,PrP)传染致病机制一直是朊粒(prion)研究领域的焦点.由正常型朊粒蛋白(PrPC)向致病型朊粒蛋白(PrPSc)的转变是致病的关键步骤.本文综述了近年来PrPC向PrPSc转变的结构变化特征、PrPSc由单体形成寡聚体的组装机制、以及PrPSc寡聚体的跨膜机制与细胞毒性间的关系等方面的研究进展.
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| 关 键 词： | 朊粒蛋白 淀粉样纤维 朊粒蛋白PrPSc寡聚体 细胞毒性 |
| 收稿时间： | 2009-9-1 |
Formation and Transmembrane Toxicity of Prion Protein Oligomer |
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| HENG Jie,WU Qi.Formation and Transmembrane Toxicity of Prion Protein Oligomer[J].Chinese Journal of Biochemistry and Molecular Biology,2010,26(2):109-115. |
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| Authors: | HENG Jie WU Qi |
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| Institution: | CollegeofBiologyandScience,SichuanAgriculturalUniversity,Yaan625000,Sichuan,China |
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| Abstract: | The isoform conversion from the normal cellular prion proteins(PrPC) into the abnormal scrapie prion proteins(PrP Sc) is a key process to convey the prion's pathogenicity.This review outlines some of the recent progress on prion researches,including the conformational changes during the conversion of PrPC to PrP Sc,the aggregation of PrP Sc monomers,and the transmembrane oligomers in relation to the cytotoxic effects. |
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| Keywords: | prion protein amyloid fibers prion protein PrPSc oligomer cytotoxicity |
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