Clinicopathologic factors and nuclear morphometry as independent prognosticators in KIT-positive gastrointestinal stromal tumors. |
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| Authors: | Sonja E. Steigen Bj?rn Straume Dmitry Turbin Andy K.W. Chan Samuel Leung Torsten O. Nielsen Sigurd Lindal |
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| Affiliation: | Department of Pathology (SES,SLindal) and Institute of Community Medicine (BS), University of Tromsø, Tromsø, Norway, and Department of Pathology and Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, Canada (SES,DT,AKWC,SLeung,TON) |
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| Abstract: | Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms found in the gastrointestinal tract. The purpose of this study was to evaluate whether morphometric measurements could complement tumor size and mitotic activity in risk evaluation. Nuclear roundness and ellipse axis ratio were found to correlate with tumor size, mitotic activity, nuclear atypia, and hemorrhage. Morphometric variables in 422 GISTs were significant for overall survival in univariate analyses but did not retain independent significance in multivariate analyses incorporating mitotic count and tumor size. Traditional variables, together with sex, location of primary tumor, and nuclear atypia, seem to be the best parameters for prognostic evaluation. |
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| Keywords: | gastrointestinal stromal tumor morphometry roundness |
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