The relaxing ori-ter balance of Mycoplasma genomes |
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Authors: | Xin Zheng ShuLin Liu |
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Institution: | (1) Department of Microbiology, Peking University Health Science Center, Beijing, 100083, China;(2) Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, T2N 4N1, Canada |
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Abstract: | Mycoplasma are wall-less bacteria with small genomes, which are thought to have resulted from massive genome reductive processes, during which the ori-ter balance may be disrupted. For technical difficulties, ori and ter have been located only in a few Mycoplasma strains. Using the Z curve method, we were able to locate turning points on the Mycoplasma genomes, with the minimum and maximum points co-locating with ori or ter in the reference genomes. Assuming Z curve correctly located ori and ter, we calculated the distances from ori to ter in both directions on the circular genome and calculated the ori-ter balance status. The Mycoplasma genomes were not balanced, possibly as a result of close association of Mycoplasma with hosts, where there would be no other microbes for Mycoplasma to compete with for nutrients, so fastest possible growth related to balanced genomes might not be needed by Mycoplasma, leading to a relaxing ori-ter balance. |
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Keywords: | Z curve Mycoplasma genome balance ori and ter evolution |
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