Solvent-free synthesis of chiral Schiff-base ligands based on ferrocene under microwave irradiation and application to enantioselective nitroaldol (Henry) reaction |
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| Authors: | Öztürk Gülşen Çolak Mehmet Demirel Nadir |
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| Institution: | 1. Department of Chemistry, University of Dicle, Diyarbak?r, Turkey;2. Department of Chemistry, University of Ahi Evran, K?r?ehir, Turkey |
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| Abstract: | Chiral Schiff-bases 3a-f based on ferrocene were designed and synthesized using solvent-free methods by mixing ferrocene carbaldehyde 1 with amino alcohols and amines 2a-f under microwave irradiation and classical method for the enantioselective nitroaldol (Henry) reaction. The Schiff-bases were obtained in shorter reaction times and improved yield under microwave irradiation method over classical method. The highest enantioselectivity was observed in ligand 3e (95% ee) when CH(2)Cl(2) was used as solvent. |
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| Keywords: | ferrocene microwave irradiation chiral Schiff‐bases nitro aldol reaction Henry reaction |
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