Synthesis of immunoreagents for detection of deoxypyrrololine, a cross-link of bone collagen |
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| Authors: | Adamczyk M Johnson D D Reddy R E |
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| Institution: | Department of Chemistry, Abbott Laboratories, Abbott Park, IL 60064-6016, USA. |
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| Abstract: | Two immunogens (5,6) and two probes (fluorescent 7 and chemiluminescent 8) were prepared from benzyl ester (-)-10. These immunoreagents (5,6 and 7,8) are useful for detection of collagen cross-link (+)-deoxypyrrololine (Dpl, 4), and for development of assays for osteoporosis. |
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