Emulsions of oil from Adenanthera pavonina L. seeds and their protective effect |
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Authors: | Anna Jaromin Robert Żarnowski Arkadiusz Kozubek |
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Institution: | (1) Department of Lipids and Liposomes, Institute of Biochemistry and Molecular Biology, University of Wrocław, Przybyszewskiego 63/77, 51–148 Wrocław, Poland;(2) Department of Medicinal Microbiology & Immunology, 424 Medical Science Centre, University of Wisconsin — Madison, 1300 University Ave, Madison, WI 53706, USA |
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Abstract: | In our previous study, we developed very stable formulations of submicron oil-in-water emulsions from Adenanthera pavonina L. (family Leguminosae, subfamily Mimosoideae) seed oil, stabilised with soybean lecithin (SPC). Continuing our research,
we introduced an additional co-emulsifier, Tween 80, to those formulations in order to decrease the size of the emulsion particles
and improve their stability. Formulations with a mean particle size ranging from 43.6 to 306.5 nm and a negative surface charge
from −45.3 to −28.5 mV were obtained. Our stability experiments also revealed that most of the tested formulations had a very
good degree of stability over a 3-month storage period, both at 4°C and at room temperature.
Since many intravenous injectable drugs exhibit lytic activity against erythrocytes, we examined this activity for the emulsion
form of cardol, a natural compound with already proven hemolytic properties. The incorporation of this agent into the emulsion
caused an evident decrease in hemolytic activity (97–99%). This highly protective effect, observed against sheep erythrocytes,
was independent of both the composition and the particle size of the emulsions used. Our studies suggest that nonionic surfactant/phospholipid-based
emulsions containing this edible oil of A. pavonina L. may be useful as an alternative formulation matrix for pharmaceutical, nutritional or cosmetic applications of otherwise
membrane-acting components. |
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Keywords: | Adenanthera pavonina L Submicron oil-in-water emulsion Hemolysis Cardol |
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