Virus-host interactomes and global models of virus-infected cells |
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| Authors: | Friedel Caroline C Haas Jürgen |
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| Institution: | 1Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, 69120 Heidelberg, Germany;2Institut für Informatik, Ludwig-Maximilians-Universität München, 80333 München, Germany;3Division of Pathway Medicine and Edinburgh Infectious Diseases, University of Edinburgh, Edinburgh EH16 4SB, UK;4Max von Pettenkofer Institut, Ludwig-Maximilians-Universität München, 80336 München, Germany |
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| Abstract: | Novel high-throughput technologies such as yeast two-hybrid and RNA interference (RNAi) screens provide the tools to study interactions between viral proteins and the host on a genomic scale. In this review, we provide an overview of studies in which these technologies were applied and of computational approaches for the analysis of the identified viral interactors in the context of the host cell. The results of these studies illustrate the advantages of integrative systems biology approaches in the investigation of viral pathogens. |
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