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A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. |
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| Authors: | Fiona M Campbell Ray Kozak Alese Wagner Judith Y Altarejos Jason R B Dyck Darrell D Belke David L Severson Daniel P Kelly Gary D Lopaschuk |
| Institution: | Department of Pharmacology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. |
| Abstract: | |
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