Progressive increase with time after sensitization in the functional affinity of T lymphocytes |
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Authors: | A M Jokipii L Jokipii |
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Institution: | Department of Serology and Bacteriology, University of Helsinki, Helsinki, Finland |
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Abstract: | The dose response relationship in peritoneal cell migration inhibition, elicited by various concentrations of ABA-Tyr, was studied in guinea pigs sensitized with a standard dose of ABA-Tyr. The reactivity to 2 × 10?7 or 2 × 10?8 mole/ml appeared at 2 wk, and remained at the maximum level from 4 wk to 8 mo after sensitization. The inhibition by 2 × 10?9 mole/ml increased up to 4 mo and 2 × 10?10 mole/ml was first inhibitory at mo. The change in the slope of the dose response curve was a property of the ABA-specific cells. As there is no B-cell response to ABA-Tyr, the finding shows that the functional affinity of specific T cells progressively increases with time after sensitization. |
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