| Fas ligand: Can it ever be tamed? |
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| 作者姓名： | RCDUKE KHANCE JSUN DCHAN SJMEECH BPIETRA DNELSON DBELLGRAU |
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| 作者单位： | Globelmmune，Inc.，Denver，Colorado，2University of Colorado School of Medicine，Denver，Colorado，Globelmmune，Inc.，Denver，Colorado，Globelmmune，Inc.，Denver，Colorado，University of Colorado School of Medicine，Denver，Colorado，Brown University S |
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| 基金项目： | This work was supported in part by USPHS-NIH SBIR grants AI-40394, AI-40607, and AI-47168. |
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| 摘 要： | Fas ligand (FasL) was first described functionally as an inducible cell surface molecule used by cytotoxic T cells to induce apoptotic cell death in tumor cells and activated lymphocytes. With the identification of Fas as the Ipr gene product, FasL became recognized as a molecule involved in down-regulation of the immune system. While FasL can be used to efficiently kill Fas-expressing tumor cells as well as activated T and B lymphocytes in vitro, attempts to use FasL therapeutically to treat cancer or to prevent transplant
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