Mechanotransduction and fibrosis |
| |
Authors: | Dominik Duscher Zeshaan N Maan Victor W Wong Robert C Rennert Michael Januszyk Melanie Rodrigues Michael Hu Arnetha J Whitmore Alexander J Whittam Michael T Longaker Geoffrey C Gurtner |
| |
Institution: | 1. Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA;2. Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA |
| |
Abstract: | Scarring and tissue fibrosis represent a significant source of morbidity in the United States. Despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development. A thorough understanding of the various signaling pathways involved is essential to formulate strategies to combat fibrosis and scarring. While initial efforts focused primarily on the biochemical mechanisms involved in scar formation, more recent research has revealed a central role for mechanical forces in modulating these pathways. Mechanotransduction, which refers to the mechanisms by which mechanical forces are converted to biochemical stimuli, has been closely linked to inflammation and fibrosis and is believed to play a critical role in scarring. This review provides an overview of our current understanding of the mechanisms underlying scar formation, with an emphasis on the relationship between mechanotransduction pathways and their therapeutic implications. |
| |
Keywords: | Mechanotransduction Mechanical signaling Fibrosis Scarring |
本文献已被 ScienceDirect 等数据库收录! |
|