The possible involvement of both calcium and cyclic AMP in the dopaminergic inhibition of prolactin secretion |
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| Authors: | J E Merritt B L Brown |
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| Institution: | Department of Human Metabolism and Clinical Biochemistry University of Sheffield Medical School Beech Hill Road Sheffield S10 2RX, U.K. |
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| Abstract: | Dopamine inhibited basal, TRH-, IBMX- and A23187-stimulated prolactin secretion from rat anterior pituitary cells. However, dopamine did not inhibit prolactin secretion stimulated by elevated K+ concentrations. These data are interpreted in terms of dopaminergic inhibition of both cyclic AMP production and Ca2+ influx through agonist-, but not voltage-, dependent Ca2+ channels. |
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