In vitro effects of some anabolic compounds on erythrocyte carbonic anhydrase I and II |
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| Authors: | Gençer Nahit Ergün Adem Demir Dudu |
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| Affiliation: | Chemistry Department/Biochemistry Div., Balikesir University, Cagis Kampus, Balikesir 10145, Turkey. ngencer@balikesir.edu.tr |
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| Abstract: | The in vitro effects of the anabolic compounds, zeranol, 17 β-estradiol, diethylstilbestrol (DES), and trenbolone, on the activity of purified human carbonic anhydrase I and II were evaluated. In vitro CA enzyme activity was determined colorimetrically using the CO? hydration method of Maren. IC?? values of the compounds that caused inhibition were determined by means of activity percentage diagrams. The IC?? concentrations of zeranol, 17 β-estradiol, DES and trenbolone on hCA I were 94, 55, 10, 898 μM and for hCA II 89, 159, 439 and 101 μM, respectively. |
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